Erlotinib Impurity 118

Erlotinib Impurity 118 - Names and Identifiers

Name	OSI-420-d4, Free Base (Desmethyl Erlotinib-d4)
Synonyms	OSI-420-d4 O-Desmethylerlotinib Erlotinib Impurity 118 [2H4]-O-Desmethylerlotinib OSI-420-d4, Free Base (Desmethyl Erlotiniβ-d4) OSI-420-d4, Free Base (Desmethyl Erlotinib-d4) 2-[[4-[(3-Ethynylphenyl-d4)aMino]-7-(2-Methoxyethoxy)-6-quinazolinyl]oxy]ethanol 2-[7-(2-methoxyethoxy)-4-(2,3,4,6-tetradeuterio-5-ethynylanilino)quinazolin-6-yl]oxyethanol
CAS	1216420-11-9

Erlotinib Impurity 118 - Physico-chemical Properties

Molecular Formula	C21H21N3O4
Molar Mass	379.40914
Melting Point	145 - 152°C
Solubility	Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Light Beige to Beige
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere
Stability	Hygroscopic

Erlotinib Impurity 118 - Introduction

OSI-420-d4,Free Base(Desmethyl Erlotinib-d4) is a compound commonly used in pharmaceutical research. The following is a description of its nature, use, formulation and safety information:

Nature:
- OSI-420-d4,Free Base is an organic compound with the chemical formula C20H17D4N4O3.
-It is the free base state of Desmethyl Erlotinib-d4, a labeled compound in which deuterium replaces some hydrogen atoms.
- OSI-420-d4,Free Base is a white solid, stable at normal temperature and pressure.

Use:
- OSI-420-d4,Free Base is mainly used in the field of drug research, especially for the development of various drugs for the treatment of cancer.
-As a metabolite of Desmethyl Erlotinib-d4, it allows researchers to track the metabolic pathway and elimination rate of the drug in the body.

Method:
- OSI-420-d4,Free Base is prepared by using substances containing deuterium in the chemical synthesis process, so that some or all hydrogen atoms can be replaced with deuterium atoms.
-The specific synthesis method can be designed and determined according to the needs of the laboratory and standard operating methods.

Safety Information:
- OSI-420-d4, the security guidelines for Free Base generally do not disclose specific information.
-As a chemical substance, use should follow laboratory safety instructions and take appropriate protective measures.
-Avoid incompatible reactions with other chemicals during handling and storage, and store them in a dry, dark, well-ventilated environment.

Last Update：2024-04-09 02:00:54